BDBM50263624 CHEMBL4081213

SMILES FC(F)(F)Oc1ccc(C[C@H](NC(=O)c2cnn(n2)-c2cccnc2)C(=O)NC2(CC2)C#N)cc1Cl

InChI Key InChIKey=LWKXXMIGWXDPTM-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50263624   

TargetCytochrome P450 3A4(Human)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263624(CHEMBL4081213)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using DBF as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263624(CHEMBL4081213)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using MFC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263624(CHEMBL4081213)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2020
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263624(CHEMBL4081213)
Affinity DataKi:  36nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2020
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263624(CHEMBL4081213)
Affinity DataKi:  353nMAssay Description:Inhibition of human CatL using Cbz-Phe-Arg-AMC as substrate measured over 30 mins by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2020
Entry Details Article
PubMed