BDBM50263814 CHEMBL4101216

SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@H](C)O)[C@@H](C)CC

InChI Key InChIKey=WQIHSOXKRYCWEW-UHFFFAOYSA-N

Data  3 KI  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50263814   

TargetMelanocortin receptor 3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50263814(CHEMBL4101216)
Affinity DataEC50:  20nMAssay Description:Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50263814(CHEMBL4101216)
Affinity DataIC50: 59nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2020
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50263814(CHEMBL4101216)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at human MC1R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50263814(CHEMBL4101216)
Affinity DataEC50:  28nMAssay Description:Agonist activity at human MC4R expressed in high doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 15 mins by HT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50263814(CHEMBL4101216)
Affinity DataEC50:  331nMAssay Description:Agonist activity at human MC4R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2020
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50263814(CHEMBL4101216)
Affinity DataKi:  3.90nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC1R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50263814(CHEMBL4101216)
Affinity DataKi:  324nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50263814(CHEMBL4101216)
Affinity DataKi:  832nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC4R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2020
Entry Details Article
PubMed