BDBM50264142 Biphenyl-2-carboxylic acid [(1R,5R)-8-(6-fluoro-naphthalen-2-ylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-amide::Biphenyl-2-carboxylic acid [8-(6-fluoro-naphthalen-2-ylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-amide::CHEMBL522295::N-(8-((6-fluoronaphthalen-2-yl)methyl)-8-azabicyclo[3.2.1]octan-3-yl)biphenyl-2-carboxamide

SMILES Fc1ccc2cc(CN3C4CCC3CC(C4)NC(=O)c3ccccc3-c3ccccc3)ccc2c1

InChI Key InChIKey=DBWKEBCQXCVXLS-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50264142   

TargetCytochrome P450 2D6(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50264142(N-(8-((6-fluoronaphthalen-2-yl)methyl)-8-azabicycl...)
Affinity DataIC50: 20nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50264142(N-(8-((6-fluoronaphthalen-2-yl)methyl)-8-azabicycl...)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50264142(N-(8-((6-fluoronaphthalen-2-yl)methyl)-8-azabicycl...)
Affinity DataIC50: 400nMAssay Description:Inhibition of human CYP2D6 by fluorescence technique in presence of NADPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50264142(N-(8-((6-fluoronaphthalen-2-yl)methyl)-8-azabicycl...)
Affinity DataIC50: 400nMAssay Description:Inhibition of human CYP2D6 by fluorescence technique in presence of NADPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50264142(N-(8-((6-fluoronaphthalen-2-yl)methyl)-8-azabicycl...)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50264142(N-(8-((6-fluoronaphthalen-2-yl)methyl)-8-azabicycl...)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50264142(N-(8-((6-fluoronaphthalen-2-yl)methyl)-8-azabicycl...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50264142(N-(8-((6-fluoronaphthalen-2-yl)methyl)-8-azabicycl...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50264142(N-(8-((6-fluoronaphthalen-2-yl)methyl)-8-azabicycl...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50264142(N-(8-((6-fluoronaphthalen-2-yl)methyl)-8-azabicycl...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed