BDBM50264193 CHEMBL4084381

SMILES CO[C@H]1CC[C@@]2(Cc3ccc(cc3[C@@]22COC(N)=N2)-c2cc(OC)cc(c2)C#N)CC1

InChI Key InChIKey=HGMWSDRCFLAMIZ-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50264193   

TargetBeta-secretase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50264193(CHEMBL4084381)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells assessed as decrease in sAPP-beta release after 16 to 17 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2020
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50264193(CHEMBL4084381)
Affinity DataKi:  13nMAssay Description:Inhibition of human BACE2 (1 to 473 residues) fused with Fc domain of IgG1 expressed in HEK293 cells preincubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50264193(CHEMBL4084381)
Affinity DataKi:  23nMAssay Description:Inhibition of human BACE1 (1 to 460 residues) fused with Fc domain of IgG1 expressed in HEK293 cells preincubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2020
Entry Details Article
PubMed