BDBM50264194 CHEMBL4093123

SMILES [2H]C1([2H])OC(N)=N[C@]11c2cc(ccc2C[C@@]11CC[C@@H](CC1)OC)-c1cncc(C)c1

InChI Key InChIKey=XMEKMASQQBIQCX-FNHLFAINSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50264194   

TargetBeta-secretase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50264194(CHEMBL4093123)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells assessed as decrease in sAPP-beta release after 16 to 17 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2020
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50264194(CHEMBL4093123)
Affinity DataKi:  710nMAssay Description:Inhibition of human BACE2 (1 to 473 residues) fused with Fc domain of IgG1 expressed in HEK293 cells preincubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50264194(CHEMBL4093123)
Affinity DataKi:  1.18E+3nMAssay Description:Inhibition of human BACE1 (1 to 460 residues) fused with Fc domain of IgG1 expressed in HEK293 cells preincubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2020
Entry Details Article
PubMed