BDBM50266205 2-(benzo[b]thiophen-3-yl)-5-(cyclohexylmethyl)-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-imidazole::CHEMBL457790

SMILES C(C1CCCCC1)c1cnc(-c2csc3ccccc23)n1C1CCC2(CC1)OCCO2

InChI Key InChIKey=QXEAZKZAJJJXTD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50266205   

LigandPNGBDBM50266205(2-(benzo[b]thiophen-3-yl)-5-(cyclohexylmethyl)-1-(...)
Affinity DataIC50: 850nMAssay Description:Antagonist activity at C5a receptor assessed as inhibition of C5a-induced elastase release in human neutrophils during degranulation preincubated 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266205(2-(benzo[b]thiophen-3-yl)-5-(cyclohexylmethyl)-1-(...)
Affinity DataIC50: 47nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed