BDBM50267251 (4Z)-4-{[(4-Amino-3-hydroxybenzyl)amino]methylene}-6-bromoisoquinoline-1,3(2H,4H)-dione::CHEMBL502651

SMILES Nc1ccc(CNC=C2C(=O)NC(=O)c3ccc(Br)cc23)cc1O

InChI Key InChIKey=JPRSNAKTVNEWER-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50267251   

TargetCyclin-dependent kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267251((4Z)-4-{[(4-Amino-3-hydroxybenzyl)amino]methylene}...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CDK1/Cyclin B1 assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267251((4Z)-4-{[(4-Amino-3-hydroxybenzyl)amino]methylene}...)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of CDK2/Cyclin E assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267251((4Z)-4-{[(4-Amino-3-hydroxybenzyl)amino]methylene}...)
Affinity DataIC50: 80nMAssay Description:Inhibition of CDK4/Cyclin D1 assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed