BDBM50267484 1-(4-(3,5-bis(trifluoromethyl)phenylsulfonyl)piperazin-1-yl)-2-(4-(trifluoromethyl)phenyl)ethanone::CHEMBL476253

SMILES FC(F)(F)c1ccc(CC(=O)N2CCN(CC2)S(=O)(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1

InChI Key InChIKey=DCVDKKGXPNGVFS-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50267484   

TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267484(1-(4-(3,5-bis(trifluoromethyl)phenylsulfonyl)piper...)
Affinity DataEC50:  1nMAssay Description:Inverse agonist activity at human recombinant CB1R expressed in CHO cells assessed as increase in forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267484(1-(4-(3,5-bis(trifluoromethyl)phenylsulfonyl)piper...)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]CP-55940 from human recombinant CB1R expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267484(1-(4-(3,5-bis(trifluoromethyl)phenylsulfonyl)piper...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]CP-55940 from human recombinant CB2R expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed