BDBM50267540 6-Cyclopentyl-4-{[(5-furan-3-yl-4-hydroxy-pyridin-2-ylmethyl)-amino]-methylene}-4H-isoquinoline-1,3-dione::CHEMBL490240

SMILES Oc1cc(CNC=C2C(=O)NC(=O)c3ccc(cc23)C2CCCC2)ncc1-c1ccoc1

InChI Key InChIKey=OZOLFJMARMOUPD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50267540   

TargetCyclin-dependent kinase 4(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267540(6-Cyclopentyl-4-{[(5-furan-3-yl-4-hydroxy-pyridin-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK4/Cyclin D1 assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267540(6-Cyclopentyl-4-{[(5-furan-3-yl-4-hydroxy-pyridin-...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of CDK2/Cyclin E assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267540(6-Cyclopentyl-4-{[(5-furan-3-yl-4-hydroxy-pyridin-...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of CDK1/Cyclin B1 assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed