BDBM50267653 CHEMBL4092171

SMILES CC(C)(C)OC(=O)Nc1ccc2OC(C)(C)CC(NC(=O)Nc3ccc(cc3)C#N)c2c1

InChI Key InChIKey=ACNMHKXKDCWNAR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50267653   

TargetNAD-dependent protein deacetylase sirtuin-2(Human)
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50267653(CHEMBL4092171)
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-2 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50267653(CHEMBL4092171)
Affinity DataIC50: 1.21E+5nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-1 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details Article
PubMed