BDBM50267839 CHEMBL4076823

SMILES C[C@]1(N)CC[C@@H](Nc2c(cnn3cc(cc23)-c2cccc(Cl)c2)C(N)=O)C1(C)C

InChI Key InChIKey=CKMCHFATUIBECF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50267839   

TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50267839(CHEMBL4076823)
Affinity DataIC50: 17nMAssay Description:Inhibition of GST-tagged JAK2 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50267839(CHEMBL4076823)
Affinity DataIC50: 20nMAssay Description:Inhibition of His-tagged TYK2 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50267839(CHEMBL4076823)
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50267839(CHEMBL4076823)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of GST-tagged JAK1 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50267839(CHEMBL4076823)
Affinity DataIC50: 780nMAssay Description:Inhibition of JAK1/JAK3 in human whole blood assessed as reduction in IL-2 induced IFN-gamma production after 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50267839(CHEMBL4076823)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human ERG by flux-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed