BDBM50267840 CHEMBL4062062

SMILES C[C@]1(N)CC[C@@H](Nc2c(cnn3cc(cc23)-c2ccc(Cl)cc2)C(N)=O)C1(C)C

InChI Key InChIKey=NJNZVVQYKKIDLH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50267840   

TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50267840(CHEMBL4062062)
Affinity DataIC50: 15nMAssay Description:Inhibition of GST-tagged JAK2 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50267840(CHEMBL4062062)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50267840(CHEMBL4062062)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of GST-tagged JAK1 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50267840(CHEMBL4062062)
Affinity DataIC50: 10nMAssay Description:Inhibition of His-tagged TYK2 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed