BDBM50267852 CHEMBL4073562

SMILES Cc1cc(ccn1)-c1cc2c(N[C@@H]3CC[C@](C)(N)C3(C)C)c(cnn2c1)C(N)=O

InChI Key InChIKey=QBNPDTYLZZYINV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50267852   

TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50267852(CHEMBL4073562)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50267852(CHEMBL4073562)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of GST-tagged JAK1 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50267852(CHEMBL4073562)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of His-tagged TYK2 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50267852(CHEMBL4073562)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of GST-tagged JAK2 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50267852(CHEMBL4073562)
Affinity DataIC50: 55nMAssay Description:Inhibition of JAK1/JAK3 in human whole blood assessed as reduction in IL-2 induced IFN-gamma production after 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50267852(CHEMBL4073562)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG by flux-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2020
Entry Details Article
PubMed