BDBM50268690 CHEMBL4077246

SMILES OC(Cn1cnnn1)(c1ccc(F)cc1F)C(F)(F)c1ccc(cn1)C#Cc1ccc(OCc2ccc(cc2)C#N)cc1

InChI Key InChIKey=UDGASIIGNCBLSI-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50268690   

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50268690(CHEMBL4077246)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of CYP17 lyase in human hepatocyte microsomes using 17a-hydroxypregnenolone substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50268690(CHEMBL4077246)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP11B2 in human hepatocyte microsomes using deoxycorticosteroid substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50268690(CHEMBL4077246)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP11B1 in human hepatocyte microsomes using deoxycortisol substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
TargetAromatase(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50268690(CHEMBL4077246)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP19 in human hepatocyte microsomes using testosterone substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50268690(CHEMBL4077246)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP17 hydroxylase in human hepatocyte microsomes using pregnenolone substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50268690(CHEMBL4077246)
Affinity DataIC50: 1.38E+5nMAssay Description:Inhibition of CYP2C19 in human hepatocyte microsomes using omeprazole substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50268690(CHEMBL4077246)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP2C9 in human hepatocyte microsomes using diclofenac substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50268690(CHEMBL4077246)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP3A4 in human hepatocyte microsomes using testosterone substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50268690(CHEMBL4077246)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP3A4 in human hepatocyte microsomes using testosterone substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed