BDBM50269388 CHEMBL4083641

SMILES Cc1nc(-n2nc(Nc3ccc(cc3)N3CCN(CC3)C3CC4CCC3C4)nc2N)c2ccccc2n1

InChI Key

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50269388   

TargetVascular endothelial growth factor receptor 2(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50269388(CHEMBL4083641)
Affinity DataEC50:  104nMAssay Description:Inhibition of VEGF stimulated VEGFR2 phosphorylation at Y165 residues in HUVEC preincubated for 1 hr followed by VEGF addition measured after 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50269388(CHEMBL4083641)
Affinity DataEC50:  397nMAssay Description:Inhibition of Axl in human HeLa cells assessed as reduction in AKT phosphorylation at Ser 473 residues pre-incubated for 1 hr before preclustered ant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50269388(CHEMBL4083641)
Affinity DataIC50: 32nMAssay Description:Inhibition of N-terminal GST-tagged human Axl (464 to 885 end residues) cytoplasmic domain expressed in baculovirus expression system using HS1 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2020
Entry Details Article
PubMed