BDBM50269580 CHEMBL4082622

SMILES COc1cc(cc(OC)c1OC)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(=O)OCCOc1ccc2ccc(=O)oc2c1

InChI Key InChIKey=GNORNMPAKCRTJW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50269580   

TargetProstaglandin G/H synthase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50269580(CHEMBL4082622)
Affinity DataIC50: 5.31E+4nMAssay Description:Inhibition of COX1 (unknown origin) assessed as reduction in PGE2 level using arachidonic acid as substrate after 5 mins in presence of heme by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50269580(CHEMBL4082622)
Affinity DataIC50: 230nMAssay Description:Inhibition of COX2 (unknown origin) assessed as reduction in PGE2 level using arachidonic acid as substrate after 5 mins in presence of heme by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50269580(CHEMBL4082622)
Affinity DataIC50: 870nMAssay Description:Inhibition of 5-LOX in Sprague Dawley rat Leukocytes assessed as reduction in calcium ionophore A23187-induced LTB4 production preincubated for 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details Article
PubMed