BDBM50270031 1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-3-(3-fluorothiophen-2-yl)-1-oxopropan-2-aminium 2,2,2-trifluoroacetate::CHEMBL515494

SMILES [NH3+]C(Cc1sccc1F)C(=O)N[C@@]1(C[C@@H]1c1ccccc1)C#N

InChI Key InChIKey=UUKJIEBFYVGYRF-UHFFFAOYSA-O

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50270031   

TargetNeutrophil elastase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270031(1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-3-(3-...)
Affinity DataIC50: 170nMAssay Description:Blockade of neutrophil elastase processing in human U937 cells after 7 days by fluorogenic substrate cleavage assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCathepsin G(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270031(1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-3-(3-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cathepsin G in human U937 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCathepsin G(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270031(1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-3-(3-...)
Affinity DataIC50: 690nMAssay Description:Inhibition of cathepsin G activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetMyeloblastin(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270031(1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-3-(3-...)
Affinity DataIC50: 150nMAssay Description:Inhibition of proteinase-3 activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetNeutrophil elastase(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270031(1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-3-(3-...)
Affinity DataIC50: 150nMAssay Description:Inhibition of neutrophil elastase activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270031(1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-3-(3-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant cathepsin B after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270031(1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-3-(3-...)
Affinity DataIC50: 1.55E+4nMAssay Description:Inhibition of human recombinant cathepsin L after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270031(1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-3-(3-...)
Affinity DataIC50: 3.34E+4nMAssay Description:Inhibition of human recombinant cathepsin S after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCathepsin G(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270031(1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-3-(3-...)
Affinity DataIC50: 90nMAssay Description:Blockade of cathepsin G processing in human U937 cells by densitometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270031(1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-3-(3-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant cathepsin H after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50270031(1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-3-(3-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of neutrophil elastase in human U937 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed