BDBM50270707 CHEMBL486495::[5-(4-tert-Butylphenyl)furan-2-yl]-(4-cyclohexylpiperazin-1-yl)-methanone

SMILES CC(C)(C)c1ccc(cc1)-c1ccc(o1)C(=O)N1CCN(CC1)C1CCCCC1

InChI Key InChIKey=HJTNQQWICWEECK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50270707   

TargetSodium channel protein type 10 subunit alpha(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270707([5-(4-tert-Butylphenyl)furan-2-yl]-(4-cyclohexylpi...)
Affinity DataIC50: 90nMAssay Description:Blockade of Nav1.8 channel in rat dorsal root ganglion neurons assessed as inhibition of TTX-R current by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270707([5-(4-tert-Butylphenyl)furan-2-yl]-(4-cyclohexylpi...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant Nav1.8 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270707([5-(4-tert-Butylphenyl)furan-2-yl]-(4-cyclohexylpi...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant Nav1.2 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270707([5-(4-tert-Butylphenyl)furan-2-yl]-(4-cyclohexylpi...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant Nav1.5 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed