BDBM50272530 CHEMBL4130208

SMILES O=S(=O)(CC1CC1)c1nnc(-c2cc(F)c(-c3cnc(Oc4ccccc4C(F)(F)F)c(Cl)c3)cc2F)[nH]1

InChI Key InChIKey=ARCUVPSLBZWKRK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50272530   

LigandChemical structure of BindingDB Monomer ID 50272530BDBM50272530(CHEMBL4130208)
Affinity DataIC50: 70nMAssay Description:Displacement of [3H]-6,6-fused heteroaryl-sulfonamide derivative from human Nav1.7 expressed in HEK293 cell membranes preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50272530BDBM50272530(CHEMBL4130208)
Affinity DataIC50: 100nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells clamped to holding potential yielding 20 to 50% inactivation assessed as reduction in peak sodium c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50272530BDBM50272530(CHEMBL4130208)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK cells at holding potential of -50 mV followed by voltage step to -120 mV by PatchXpress electrophysiology...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2020
Entry Details Article
PubMed