BDBM50272647 CHEMBL498495::N-methyl((3S,4R)-4-(o-tolyloxy)-3,4-dihydro-2H-chromen-3-yl)methanamine::N-methyl((3S,4R)-4-(o-tolyloxy)chroman-3-yl)methanamine

SMILES CNC[C@H]1COc2ccccc2[C@@H]1Oc1ccccc1C

InChI Key InChIKey=AROKURNCLIVVKP-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50272647   

TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272647(N-methyl((3S,4R)-4-(o-tolyloxy)chroman-3-yl)methan...)
Affinity DataIC50: 200nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272647(N-methyl((3S,4R)-4-(o-tolyloxy)chroman-3-yl)methan...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272647(N-methyl((3S,4R)-4-(o-tolyloxy)chroman-3-yl)methan...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272647(N-methyl((3S,4R)-4-(o-tolyloxy)chroman-3-yl)methan...)
Affinity DataIC50: 200nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272647(N-methyl((3S,4R)-4-(o-tolyloxy)chroman-3-yl)methan...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272647(N-methyl((3S,4R)-4-(o-tolyloxy)chroman-3-yl)methan...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272647(N-methyl((3S,4R)-4-(o-tolyloxy)chroman-3-yl)methan...)
Affinity DataIC50: 210nMAssay Description:Inhibition of recombinant CYP32D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed