BDBM50272693 CHEMBL498141::N-methyl((3R,4R)-4-(2-(trifluoromethyl)phenoxy)-3,4-dihydro-1H-isochromen-3-yl)methanamine

SMILES CNC[C@H]1OCc2ccccc2[C@H]1Oc1ccccc1C(F)(F)F

InChI Key InChIKey=DKMITNDZRUDDGX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50272693   

TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272693(N-methyl((3R,4R)-4-(2-(trifluoromethyl)phenoxy)-3,...)
Affinity DataIC50: 900nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272693(N-methyl((3R,4R)-4-(2-(trifluoromethyl)phenoxy)-3,...)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272693(N-methyl((3R,4R)-4-(2-(trifluoromethyl)phenoxy)-3,...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272693(N-methyl((3R,4R)-4-(2-(trifluoromethyl)phenoxy)-3,...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant CYP32D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed