BDBM50272717 CHEMBL505433::N-methyl((3S,4S)-4-(o-tolyloxy)-3,4-dihydro-1H-isochromen-3-yl)methanamine::N-methyl((3S,4S)-4-(o-tolyloxy)isochroman-3-yl)methanamine

SMILES CNC[C@@H]1OCc2ccccc2[C@@H]1Oc1ccccc1C

InChI Key InChIKey=FHNHVNKWEHYJDJ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50272717   

TargetSodium-dependent dopamine transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272717(N-methyl((3S,4S)-4-(o-tolyloxy)-3,4-dihydro-1H-iso...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272717(N-methyl((3S,4S)-4-(o-tolyloxy)-3,4-dihydro-1H-iso...)
Affinity DataIC50: 18nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272717(N-methyl((3S,4S)-4-(o-tolyloxy)-3,4-dihydro-1H-iso...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272717(N-methyl((3S,4S)-4-(o-tolyloxy)-3,4-dihydro-1H-iso...)
Affinity DataIC50: 5nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272717(N-methyl((3S,4S)-4-(o-tolyloxy)-3,4-dihydro-1H-iso...)
Affinity DataIC50: 900nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272717(N-methyl((3S,4S)-4-(o-tolyloxy)-3,4-dihydro-1H-iso...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272717(N-methyl((3S,4S)-4-(o-tolyloxy)-3,4-dihydro-1H-iso...)
Affinity DataIC50: 800nMAssay Description:Inhibition of recombinant CYP32D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed