BDBM50272809 CHEMBL525725::N-[1-(3-Fluoro-benzyl)-1H-indazol-5-yl]-5-{[4-methoxy-phenylimino]-methyl}-pyrimidine-4,6-diamine

SMILES COc1ccc(cc1)\N=C\c1c(N)ncnc1Nc1ccc2n(Cc3cccc(F)c3)ncc2c1

InChI Key InChIKey=DRLWGTWSWZETCV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50272809   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272809(N-[1-(3-Fluoro-benzyl)-1H-indazol-5-yl]-5-{[4-meth...)
Affinity DataIC50: 118nMAssay Description:Inhibition of human ErbB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272809(N-[1-(3-Fluoro-benzyl)-1H-indazol-5-yl]-5-{[4-meth...)
Affinity DataIC50: 49nMAssay Description:Inhibition of human EGFR expressed in SF9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272809(N-[1-(3-Fluoro-benzyl)-1H-indazol-5-yl]-5-{[4-meth...)
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of human ErB2 phosphorylation in human SKBR3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed