BDBM50272977 CHEMBL4129002

SMILES [H][C@]12C[C@H]([C@H](Oc3ccc(cc3)C#N)[C@@]1(C)CC[C@@H](C2)C(F)F)N1CCC[C@@H](N)C1

InChI Key InChIKey=UXJLMBOKOQNNEP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50272977   

LigandPNGBDBM50272977(CHEMBL4129002)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells at holding potential of -80 mV after 5 mins by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2020
Entry Details Article
PubMed
TargetShort transient receptor potential channel 6(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50272977(CHEMBL4129002)
Affinity DataIC50: 200nMAssay Description:Inhibition of human TRPC6 expressed in HEK293 cells assessed as decrease in intracellular calcium level after 24 hrs by Fluo-4 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2020
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50272977(CHEMBL4129002)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells at -80 mV holding potential after 5 mins by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2020
Entry Details Article
PubMed