BDBM50272979 CHEMBL509968::N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-1-(2-(trifluoromethyl)phenyl)piperidine-4-carboxamide

SMILES FC(F)(F)c1ccccc1N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1

InChI Key InChIKey=DLQYCUAUNGADOX-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50272979   

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272979(N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-...)
Affinity DataKi:  68nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272979(N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-...)
Affinity DataIC50: 380nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed