BDBM50273706 5-Pyridin-3-yl-1,3-dihydro-2H-indol-2-one::CHEMBL459071::US11542274, Compound 056

SMILES O=C1Cc2cc(ccc2N1)-c1cccnc1

InChI Key InChIKey=LRXSVYIRRDZVNQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50273706   

TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50273706(5-Pyridin-3-yl-1,3-dihydro-2H-indol-2-one | CHEMBL...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79 MZh cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50273706(5-Pyridin-3-yl-1,3-dihydro-2H-indol-2-one | CHEMBL...)
Affinity DataIC50: 5.95E+3nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79 MZh cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50273706(5-Pyridin-3-yl-1,3-dihydro-2H-indol-2-one | CHEMBL...)
Affinity DataIC50: 6.58E+3nMAssay Description:Inhibition of human recombinant CYP1A2 expressed in baculovirus-infected insect microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein cereblon(Human)
Agency For Science, Technology and Research (A*Star)

US Patent
LigandPNGBDBM50273706(5-Pyridin-3-yl-1,3-dihydro-2H-indol-2-one | CHEMBL...)
Affinity DataIC50: 2.00E+5nMAssay Description:Fluorescence quenching end point measurements were performed in black polystyrene 384-plates on Tecan Safire monochromator reader with the following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
US Patent