BDBM50273777 1-Ethyl-6-pyridin-3-yl-3,4-dihydroquinolin-2(1H)-one::CHEMBL457425

SMILES CCN1C(=O)CCc2cc(ccc12)-c1cccnc1

InChI Key InChIKey=JHQOUGAVAKNADW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50273777   

TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50273777(1-Ethyl-6-pyridin-3-yl-3,4-dihydroquinolin-2(1H)-o...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79 MZh cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50273777(1-Ethyl-6-pyridin-3-yl-3,4-dihydroquinolin-2(1H)-o...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79 MZh cells assessed as conversion of [4-14C]-11-deoxycorticosterone substrate by HPTLC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50273777(1-Ethyl-6-pyridin-3-yl-3,4-dihydroquinolin-2(1H)-o...)
Affinity DataIC50: 3.48E+3nMAssay Description:Inhibition of human recombinant CYP1A2 expressed in baculovirus-infected insect microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50273777(1-Ethyl-6-pyridin-3-yl-3,4-dihydroquinolin-2(1H)-o...)
Affinity DataIC50: 3.48E+3nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50273777(1-Ethyl-6-pyridin-3-yl-3,4-dihydroquinolin-2(1H)-o...)
Affinity DataIC50: 5.18E+3nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79 MZh cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed