BDBM50274385 4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]phenyl}-amino)-7-[(1E)-4-(4-ethylpiperazin-1-yl)but-1-enyl]quinoline-3-carbonitrile::CHEMBL489058

SMILES CCN1CCN(CC\C=C\c2ccc3c(Nc4ccc(Sc5nccn5C)c(Cl)c4)c(cnc3c2)C#N)CC1

InChI Key InChIKey=OYAMULIHRWEUAR-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50274385   

LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3Kalpha in presence of 25 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of AKT in presence of 20 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of mTOR in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of Tpl2 in presence of 50 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MK2 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50: 225nMAssay Description:Inhibition of MEK1-mediated ERK phosphorylation in human WM266-4 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50: 12nMAssay Description:Inhibition of MEK1 by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50: 55nMAssay Description:Inhibition of Src in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50: 58nMAssay Description:Inhibition of Lyn in presence of 20 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KDR in presence of 1 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of PDK1 in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of B-raf in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50: 9.17E+3nMAssay Description:Inhibition of IKK-beta in presence of 2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of P70S6 in presence of 2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)
Affinity DataIC50: 2.74E+4nMAssay Description:Inhibition of PKCtheta in presence of 6 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed