BDBM50275434 CHEMBL4127458

SMILES Cc1cncc(n1)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl

InChI Key InChIKey=ZRWWXYPLGSDQJG-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50275434   

LigandPNGBDBM50275434(CHEMBL4127458)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of PCSK9 translation in human THP-1 cells by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50275434(CHEMBL4127458)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50275434(CHEMBL4127458)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50275434(CHEMBL4127458)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50275434(CHEMBL4127458)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50275434(CHEMBL4127458)
Affinity DataKi:  3.82E+4nMAssay Description:Inhibition of dofetilide binding to human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50275434(CHEMBL4127458)
Affinity DataIC50: 5.98E+4nMAssay Description:Inhibition of human ERG by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details Article
PubMed