BDBM50275983 CHEMBL472441::N1-[3-(1H-Imidazol-4-yl)propyl]-N2-[3-phenyl-3-(thiazol-2-yl)propanoyl]guanidine

SMILES NC(NC(=O)CC(c1nccs1)c1ccccc1)=NCCCc1cnc[nH]1

InChI Key InChIKey=SGQYOPBUMICDBU-UHFFFAOYSA-N

Data  1 Kd  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50275983   

TargetHistamine H2 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50275983(N1-[3-(1H-Imidazol-4-yl)propyl]-N2-[3-phenyl-3-(th...)
Affinity DataEC50:  120nMAssay Description:Activity at human recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50275983(N1-[3-(1H-Imidazol-4-yl)propyl]-N2-[3-phenyl-3-(th...)
Affinity DataEC50:  14nMAssay Description:Activity at guinea pig recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50275983(N1-[3-(1H-Imidazol-4-yl)propyl]-N2-[3-phenyl-3-(th...)
Affinity DataEC50:  66.3nMAssay Description:Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50275983(N1-[3-(1H-Imidazol-4-yl)propyl]-N2-[3-phenyl-3-(th...)
Affinity DataEC50:  38.0nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50275983(N1-[3-(1H-Imidazol-4-yl)propyl]-N2-[3-phenyl-3-(th...)
Affinity DataKd:  4.68E+3nMAssay Description:Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed