BDBM50276025 CHEMBL511625::N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(spiro[indoline-3,4'-piperidine]-1'-yl)nicotinamide

SMILES Nc1ccc(cc1NC(=O)c1ccc(nc1)N1CCC2(CNc3ccccc23)CC1)-c1cccs1

InChI Key InChIKey=YBCAQIYOMLXOOO-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50276025   

TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50276025(N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(spiro[indol...)
Affinity DataIC50: 230nMAssay Description:Inhibition of human HDAC1 expressed in mammalian cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50276025(N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(spiro[indol...)
Affinity DataKi:  1.03E+4nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed