BDBM50277582 2-(3-(7-hydroxy-4,5-dihydropyrazolo[1,5-a]quinolin-3-yl)propanamido)benzoic acid::CHEMBL482768

SMILES OC(=O)c1ccccc1NC(=O)CCc1cnn-2c1CCc1cc(O)ccc-21

InChI Key InChIKey=PCUNTWOSLIUDRR-UHFFFAOYSA-N

Data  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50277582   

TargetCytochrome P450 2C8(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277582(2-(3-(7-hydroxy-4,5-dihydropyrazolo[1,5-a]quinolin...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using montelukast substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277582(2-(3-(7-hydroxy-4,5-dihydropyrazolo[1,5-a]quinolin...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277582(2-(3-(7-hydroxy-4,5-dihydropyrazolo[1,5-a]quinolin...)
Affinity DataEC50:  2.70E+3nMAssay Description:Agonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277582(2-(3-(7-hydroxy-4,5-dihydropyrazolo[1,5-a]quinolin...)
Affinity DataIC50: 13nMAssay Description:Displacement of [3H]niacin from human GPR109A expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277582(2-(3-(7-hydroxy-4,5-dihydropyrazolo[1,5-a]quinolin...)
Affinity DataEC50:  64nMAssay Description:Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed