BDBM50278631 CHEMBL4162785::US10399948, Compound 22

SMILES O=c1cc(OCCOc2ccccc2)ccn1-c1cccc(c1)C#N

InChI Key InChIKey=LCTMXHIKBVVKNU-UHFFFAOYSA-N

Data  5 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50278631   

TargetMetabotropic glutamate receptor 3(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278631(CHEMBL4162785 | US10399948, Compound 22)
Affinity DataIC50: 340nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278631(CHEMBL4162785 | US10399948, Compound 22)
Affinity DataEC50:  6.00E+3nMAssay Description:Positive allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as increase in glutamate induced-calcium mobilization preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278631(CHEMBL4162785 | US10399948, Compound 22)
Affinity DataIC50: 339nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278631(CHEMBL4162785 | US10399948, Compound 22)
Affinity DataEC50:  6.31E+3nMAssay Description:Positive allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as increase in glutamate induced-calcium mobilization preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278631(CHEMBL4162785 | US10399948, Compound 22)
Affinity DataIC50: 559nMAssay Description:Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Rat)
Vanderbilt University

US Patent
LigandPNGBDBM50278631(CHEMBL4162785 | US10399948, Compound 22)
Affinity DataIC50: 3.00E+4nMAssay Description:Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278631(CHEMBL4162785 | US10399948, Compound 22)
Affinity DataIC50: 6.02E+3nMAssay Description:HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent