BDBM50278942 CHEMBL499905::D-2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(1-(4-methoxybenzyl)-1H-indol-3-yl)propanoic acid

SMILES COc1ccc(Cn2cc(C[C@@H](NS(=O)(=O)c3ccc(OCC#CC)cc3)C(O)=O)c3ccccc23)cc1

InChI Key InChIKey=JUSNXCIZGYMOPC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50278942   

LigandPNGBDBM50278942(D-2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(1-(4-m...)
Affinity DataIC50: 80nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50278942(D-2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(1-(4-m...)
Affinity DataIC50: 1.44E+3nMAssay Description:Inhibition of MMP2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50278942(D-2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(1-(4-m...)
Affinity DataIC50: 4.56E+3nMAssay Description:Inhibition of MMP13 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50278942(D-2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(1-(4-m...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of MMP14 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50278942(D-2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(1-(4-m...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MMP1 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50278942(D-2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(1-(4-m...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of TACE in mouse Raw264.7 cells assessed as inhibition of LPS-induced TNFalpha production treated 1 hr before LPS challenge measured 4 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed