BDBM50279314 CHEMBL4173646::US20250346593, Example 11

SMILES COc1cc2ncc(-c3ccnc(N)c3)n2cc1S(=O)(=O)C(C)(C)C

InChI Key InChIKey=XAKWGUFILBMXGB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50279314   

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Interline Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50279314BDBM50279314(CHEMBL4173646 | US20250346593, Example 11)
Affinity DataIC50: 11.3nMAssay Description:For the assay, 50 nL of a 100-fold concentrated solution of each test compound in DMSO was pipetted into either a black low volume 384-well microtite...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Interline Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50279314BDBM50279314(CHEMBL4173646 | US20250346593, Example 11)
Affinity DataIC50: 29nMAssay Description:Inhibition of RIPK2 in human PBMCs assessed as reduction in MDP-stimulated IL8 secretion measured after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2020
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Interline Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50279314BDBM50279314(CHEMBL4173646 | US20250346593, Example 11)
Affinity DataIC50: 29nMAssay Description:Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2020
Entry Details Article
PubMed