BDBM50279369 CHEMBL460562::cis-2-(3-Pyridinyl)octahydropyrrolo[3,4-c]pyrrole Dihydrochloride

SMILES C1NC[C@@H]2CN(C[C@H]12)c1cccnc1

InChI Key InChIKey=KOMXDDRATCALPT-UHFFFAOYSA-N

Data  4 KI  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50279369   

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50279369(cis-2-(3-Pyridinyl)octahydropyrrolo[3,4-c]pyrrole ...)
Affinity DataEC50:  40nMAssay Description:Agonist activity at human recombinant alpha4beta2 nicotinic acetylcholine receptor expressed in HEK293 cells assessed as changes in intracellular cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50279369(cis-2-(3-Pyridinyl)octahydropyrrolo[3,4-c]pyrrole ...)
Affinity DataEC50:  4.47E+3nMAssay Description:Agonist activity at human recombinant alpha7 nicotinic acetylcholine receptor expressed in xenopus laevis oocytes by parallel oocyte electrophysiolog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50279369(cis-2-(3-Pyridinyl)octahydropyrrolo[3,4-c]pyrrole ...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human nAChR alpha4beta2 receptor expressed in human HEK293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50279369(cis-2-(3-Pyridinyl)octahydropyrrolo[3,4-c]pyrrole ...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human nAChR alpha4beta2 receptor expressed in human HEK293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50279369(cis-2-(3-Pyridinyl)octahydropyrrolo[3,4-c]pyrrole ...)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]cytisine from alpha4beta2 nicotinic acetylcholine receptor in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50279369(cis-2-(3-Pyridinyl)octahydropyrrolo[3,4-c]pyrrole ...)
Affinity DataKi:  0.126nMAssay Description:Displacement of [3H]cytisine from nAChR alpha4beta2 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50279369(cis-2-(3-Pyridinyl)octahydropyrrolo[3,4-c]pyrrole ...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]cytisine from nAChR alpha4beta2 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50279369(cis-2-(3-Pyridinyl)octahydropyrrolo[3,4-c]pyrrole ...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]A585539 from alpha7 nicotinic acetylcholine receptor in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed