BDBM50279877 CHEMBL67352::N-Pyridin-4-yl-nicotinamide::US9409868, 3

SMILES O=C(Nc1ccncc1)c1cccnc1

InChI Key InChIKey=HVLLFBPOFNSPRN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50279877   

TargetRho-associated protein kinase 1 [1-535](Human)
H. Lee Moffin Cancer Center and Research Institute

US Patent
LigandPNGBDBM50279877(N-Pyridin-4-yl-nicotinamide | CHEMBL67352 | US9409...)
Affinity DataIC50: 7.55E+4nMpH: 7.5 T: 2°CAssay Description:A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
H. Lee Moffin Cancer Center and Research Institute

US Patent
LigandPNGBDBM50279877(N-Pyridin-4-yl-nicotinamide | CHEMBL67352 | US9409...)
Affinity DataIC50: 5.59E+4nMpH: 7.5 T: 2°CAssay Description:A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Lck(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50279877(N-Pyridin-4-yl-nicotinamide | CHEMBL67352 | US9409...)
Affinity DataIC50: 2.12E+6nMAssay Description:Inhibition of angiotensin I phosphorylation catalyzed by the protein-tyrosine kinase p56 lck partially purified from bovine thymus.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetRho-associated protein kinase 2(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50279877(N-Pyridin-4-yl-nicotinamide | CHEMBL67352 | US9409...)
Affinity DataIC50: 5.59E+4nMAssay Description:Inhibition of ROCK2 after 1 hr by FRET-based enzyme-coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50279877(N-Pyridin-4-yl-nicotinamide | CHEMBL67352 | US9409...)
Affinity DataIC50: 7.55E+4nMAssay Description:Inhibition of human His-puritin-tagged ROCK1 expressed in Sf9 cells after 1 hr by FRET-based enzyme-coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed