BDBM50280404 CHEMBL4170106

SMILES [#6]-[#8]-c1cnc(cn1)-[#6](=O)-[#7]-c1ccc(F)c(c1)[C@@]1([#6])[#7]=[#6](-[#7])-[#6]-[#8]\[#6]1=[#6](\F)F

InChI Key InChIKey=ZSFQOFQWXCDVQZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50280404   

TargetBeta-secretase 1(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50280404(CHEMBL4170106)
Affinity DataIC50: 35nMAssay Description:Inhibition of BACE1 in human SKNBE2 cells transfected with APP695 protein assessed as reduction in amyloid beta (1 to 42) levels after 18 hrs by sand...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50280404(CHEMBL4170106)
Affinity DataIC50: 151nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP derived polypeptide harboring Lys-Met/Asn-Leu mutation as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50280404(CHEMBL4170106)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cell membranes by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed