BDBM50281297 CHEMBL4170114

SMILES COc1cc2c(NC3CCN(C)CC3)cc(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1

InChI Key InChIKey=RLQLKZTYUYIWDB-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50281297   

TargetHistone deacetylase 1(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50281297(CHEMBL4170114)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length human C-terminal His-tagged/C-terminal Flag-tagged HDAC1 using fluorogenic acetylated peptide as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
National Institute of Technology Durgapur

Curated by ChEMBL
LigandPNGBDBM50281297(CHEMBL4170114)
Affinity DataIC50: 8nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Victoria University of Wellington

Curated by ChEMBL
LigandPNGBDBM50281297(CHEMBL4170114)
Affinity DataIC50: 382nMAssay Description:Inhibition of DNMT1 (unknown origin) using biotinylated histone monomethyl-H3K9 peptide by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
National Institute of Technology Durgapur

Curated by ChEMBL
LigandPNGBDBM50281297(CHEMBL4170114)
Affinity DataIC50: 8nMAssay Description:Inhibition of G9a (unknown origin) using biotinylated histone monomethyl-H3K9 peptide by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Victoria University of Wellington

Curated by ChEMBL
LigandPNGBDBM50281297(CHEMBL4170114)
Affinity DataIC50: 382nMAssay Description:Inhibition of human DNMT1 enzyme using polydeoxy-inosine polydeoxy-cytosine DNA as substrate incubated for 15 mins in presence of SAM by TR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
National Institute of Technology Durgapur

Curated by ChEMBL
LigandPNGBDBM50281297(CHEMBL4170114)
Affinity DataIC50: 8nMAssay Description:Inhibition of human G9a enzyme using histone monomethyl-H3K9 peptide as substrate incubated for 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50281297(CHEMBL4170114)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length human N-terminal GST-tagged HDAC6 using fluorogenic acetylated peptide as substrate incubated for 30 mins by fluorescence p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50281297(CHEMBL4170114)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length human C-terminal His-tagged HDAC3/human N-terminal GST-agged NCOR2 using fluorogenic acetylated peptide as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50281297(CHEMBL4170114)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length human C-terminal His-tagged HDAC2 using fluorogenic acetylated peptide as substrate incubated for 30 mins by fluorescence p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Victoria University of Wellington

Curated by ChEMBL
LigandPNGBDBM50281297(CHEMBL4170114)
Affinity DataIC50: 382nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
National Institute of Technology Durgapur

Curated by ChEMBL
LigandPNGBDBM50281297(CHEMBL4170114)
Affinity DataIC50: 16nMAssay Description:Inhibition of G9a (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Victoria University of Wellington

Curated by ChEMBL
LigandPNGBDBM50281297(CHEMBL4170114)
Affinity DataIC50: 382nMAssay Description:Inhibition of DNMT1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
National Institute of Technology Durgapur

Curated by ChEMBL
LigandPNGBDBM50281297(CHEMBL4170114)
Affinity DataIC50: 8nMAssay Description:Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Wuxi Apptec (Tianjin) Co.

Curated by ChEMBL
LigandPNGBDBM50281297(CHEMBL4170114)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Tracer Red binding to human ERG in membranes after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Wuxi Apptec (Tianjin) Co.

Curated by ChEMBL
LigandPNGBDBM50281297(CHEMBL4170114)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Tracer Red binding to human ERG in membranes after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Victoria University of Wellington

Curated by ChEMBL
LigandPNGBDBM50281297(CHEMBL4170114)
Affinity DataIC50: 382nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
National Institute of Technology Durgapur

Curated by ChEMBL
LigandPNGBDBM50281297(CHEMBL4170114)
Affinity DataIC50: 8nMAssay Description:Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed