BDBM50283309 2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbonylaminosulphonyl)-biphenyl-4-ylmethyl)-6-(isopropylaminocarbonylamino)-3H-quinazolin-4-one::CHEMBL307430

SMILES CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1

InChI Key InChIKey=GONBGRAZGKAXAL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50283309   

TargetType-2 angiotensin II receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50283309(2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Affinity DataIC50: 0.560nMAssay Description:In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

TargetType-1 angiotensin II receptor(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50283309(2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Affinity DataIC50: 0.920nMAssay Description:In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

TargetType-2 angiotensin II receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50283309(2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Affinity DataIC50: 6.5nMAssay Description:In vivo inhibitory concentration against AT2 receptor of human adrenal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

TargetType-1 angiotensin II receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50283309(2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Affinity DataIC50: 7.20nMAssay Description:In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

TargetType-2 angiotensin II receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50283309(2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Affinity DataIC50: 0.800nMAssay Description:In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

LigandPNGBDBM50283309(2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Affinity DataIC50: 0.640nMAssay Description:In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article