BDBM50285590 CHEMBL4172420

SMILES COc1cc2ccn(CCCCOc3cccc(NC(=O)CCCCCCC(=O)NO)c3)c2c(OC)c1OC

InChI Key InChIKey=TWIPDOQQXDCJOF-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50285590   

TargetHistone deacetylase 6(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285590(CHEMBL4172420)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC6 using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2020
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285590(CHEMBL4172420)
Affinity DataIC50: 29nMAssay Description:Inhibition of C-terminal FLAG/His-tagged full length recombinant human HDAC1 expressed in baculovirus infected Sf9 insect cells using KI 177 as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2020
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285590(CHEMBL4172420)
Affinity DataIC50: 108nMAssay Description:Inhibition of C-terminal His-tagged/N-terminal GST-tagged full length recombinant human HDAC3/NcoR2 expressed in baculovirus infected Sf9 insect cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2020
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285590(CHEMBL4172420)
Affinity DataIC50: 752nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC8 (1 to 377 residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys(TFA)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2020
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285590(CHEMBL4172420)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full length recombinant human HDAC2 expressed in baculovirus infected Sf9 insect cells using KI 177 as substrate preincubated for 5 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2020
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285590(CHEMBL4172420)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human HDAC5 preincubated for 5 mins followed by substrate addition measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2020
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285590(CHEMBL4172420)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST/C-terminal His-tagged recombinant human HDAC4 (648 to 1057 residues) expressed in baculovirus infected Sf9 insect cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2020
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285590(CHEMBL4172420)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC7 expressed in baculovirus infected Sf9 insect cells preincubated for 5 mins followed by substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2020
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50285590(CHEMBL4172420)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC9 expressed in baculovirus infected Sf9 insect cells preincubated for 5 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2020
Entry Details Article
PubMed