BDBM50286450 CHEMBL128135::US20240150396, Compound 28 LL205::[(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester

SMILES O=C[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1

InChI Key InChIKey=OIKITZBTDSAJQH-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50286450   

TargetProcathepsin L(Human)
Texas A&M University

US Patent
LigandPNGBDBM50286450([(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-2-pheny...)
Affinity DataKi:  0.310nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM50286450([(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-2-pheny...)
Affinity DataKi:  0.440nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM50286450([(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-2-pheny...)
Affinity DataKi:  0.440nMAssay Description:Time dependent inhibition of Trypanosoma cruzi cruzain using Cbz-Phe-Arg-AMC as substrate assessed as inhibition constant for EI complex measured for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50286450([(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-2-pheny...)
Affinity DataIC50: 400nMAssay Description:Inhibition of Calpain 1 by [3H]acetyl-casein assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

US Patent
LigandPNGBDBM50286450([(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-2-pheny...)
Affinity DataKi: >1.00E+4nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent