BDBM502871 (2R)-2-methyl-N-{2-[1-(thiophen-2-ylmethyl)piperidin-4- yl]ethyl}-4-(3,4,5-trifluorophenyl)piperazine-1-carboxamide::US11033539, Cpd. No. 6-26

SMILES C[C@@H]1CN(CCN1C(=O)NCCC1CCN(Cc2cccs2)CC1)c1cc(F)c(F)c(F)c1

InChI Key InChIKey=VJPSKBYMCHVXKK-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 502871   

TargetMuscarinic acetylcholine receptor M4(Human)
Neurocrine Biosciences

US Patent
LigandPNGBDBM502871(US11033539, Cpd. No. 6-26 | (2R)-2-methyl-N-{2-[1-...)
Affinity DataKi: <10nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Neurocrine Biosciences

US Patent
LigandPNGBDBM502871(US11033539, Cpd. No. 6-26 | (2R)-2-methyl-N-{2-[1-...)
Affinity DataKi:  55nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Neurocrine Biosciences

US Patent
LigandPNGBDBM502871(US11033539, Cpd. No. 6-26 | (2R)-2-methyl-N-{2-[1-...)
Affinity DataKi: >100nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M5(Human)
Neurocrine Biosciences

US Patent
LigandPNGBDBM502871(US11033539, Cpd. No. 6-26 | (2R)-2-methyl-N-{2-[1-...)
Affinity DataKi: >100nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M1(Human)
Neurocrine Biosciences

US Patent
LigandPNGBDBM502871(US11033539, Cpd. No. 6-26 | (2R)-2-methyl-N-{2-[1-...)
Affinity DataKi:  550nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent