BDBM50287430 (S)-2-[(1-{[(R)-1-((S)-6-Amino-2-methanesulfonylamino-hexanoylamino)-2-phenyl-ethyl]-hydroxy-phosphinoylmethyl}-cyclopentanecarbonyl)-amino]-3-(1H-indol-3-yl)-propionic acid::CHEMBL43370

SMILES CS(=O)(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)P(O)(=O)CC1(CCCC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O

InChI Key InChIKey=UBQFBYMIHFXWBF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50287430   

TargetAngiotensin-converting enzyme(Human)
Cea

Curated by ChEMBL
LigandPNGBDBM50287430((S)-2-[(1-{[(R)-1-((S)-6-Amino-2-methanesulfonylam...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human somatic ACE C-terminal domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Cea

Curated by ChEMBL
LigandPNGBDBM50287430((S)-2-[(1-{[(R)-1-((S)-6-Amino-2-methanesulfonylam...)
Affinity DataIC50: 80nMAssay Description:Inhibition of human somatic ECE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetNeprilysin(Human)
Cea

Curated by ChEMBL
LigandPNGBDBM50287430((S)-2-[(1-{[(R)-1-((S)-6-Amino-2-methanesulfonylam...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human somatic NEPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetNeprilysin(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50287430((S)-2-[(1-{[(R)-1-((S)-6-Amino-2-methanesulfonylam...)
Affinity DataIC50: 90nMAssay Description:Compound was measured for the inhibition of neutral endopeptidase 24.11(NEP).More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetEndothelin-converting enzyme 1(Human)
Cea

Curated by ChEMBL
LigandPNGBDBM50287430((S)-2-[(1-{[(R)-1-((S)-6-Amino-2-methanesulfonylam...)
Affinity DataIC50: 70nMAssay Description:In vitro inhibition of phosphoramidon-sensitive membrane bound zinc metalloprotease Endothelin-converting enzyme from partially purified guinea pig l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetAngiotensin-converting enzyme(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50287430((S)-2-[(1-{[(R)-1-((S)-6-Amino-2-methanesulfonylam...)
Affinity DataIC50: 2.5nMAssay Description:Compound was measured for the inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article