BDBM50287563 CHEMBL4174143::US11572354, Compound 9g

SMILES Brc1ccc2[nH]c(cc2c1)-c1cncn1CC1CCCCN1

InChI Key InChIKey=KAKIPBBHSOKMEY-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50287563   

TargetIndoleamine 2,3-dioxygenase 1(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50287563(CHEMBL4174143 | US11572354, Compound 9g)
Affinity DataEC50:  1.07E+4nMAssay Description:Inhibition of human IDO1 expressed in HEK293 cells assessed as reduction in kynurenine production after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50287563(CHEMBL4174143 | US11572354, Compound 9g)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human IDO1 assessed as reduction in kynurenine production using L-tryptophan as substrate after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50287563(CHEMBL4174143 | US11572354, Compound 9g)
Affinity DataIC50: 1.00E+5nMAssay Description:A standard reaction mixture (200uL/well) containing 50mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH), 200 ug/mL ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent