BDBM50287568 CHEMBL4172071::US11572354, Compound 10h

SMILES Oc1ccc(cc1)-c1cncn1Cc1cc2cc(F)ccc2[nH]1

InChI Key InChIKey=PQEQVJRKWGMMKW-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50287568   

TargetIndoleamine 2,3-dioxygenase 1(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50287568(CHEMBL4172071 | US11572354, Compound 10h)
Affinity DataEC50:  4.56E+3nMAssay Description:Inhibition of recombinant human IDO1 assessed as reduction in kynurenine production using L-tryptophan as substrate after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50287568(CHEMBL4172071 | US11572354, Compound 10h)
Affinity DataIC50: 8.33E+4nMAssay Description:Inhibition of recombinant human IDO1 assessed as reduction in kynurenine production using L-tryptophan as substrate after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50287568(CHEMBL4172071 | US11572354, Compound 10h)
Affinity DataIC50: 8.33E+4nMAssay Description:A standard reaction mixture (200uL/well) containing 50mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH), 200 ug/mL ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent