BDBM50287574 CHEMBL4162371::US11572354, Compound 9c

SMILES Brc1ccc2[nH]c(cc2c1)-c1cncn1Cc1ccc(cc1)-c1ccccc1

InChI Key InChIKey=DTJYBOUDGQQXLH-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50287574   

TargetIndoleamine 2,3-dioxygenase 1(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50287574(CHEMBL4162371 | US11572354, Compound 9c)
Affinity DataEC50:  3.09E+3nMAssay Description:Inhibition of human IDO1 expressed in HEK293 cells assessed as reduction in kynurenine production after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50287574(CHEMBL4162371 | US11572354, Compound 9c)
Affinity DataIC50: 3.40E+4nMAssay Description:A standard reaction mixture (200uL/well) containing 50mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH), 200 ug/mL ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50287574(CHEMBL4162371 | US11572354, Compound 9c)
Affinity DataIC50: 3.42E+4nMAssay Description:Inhibition of recombinant human IDO1 assessed as reduction in kynurenine production using L-tryptophan as substrate after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMed