BDBM50287582 CHEMBL4174828::US11572354, Compound 9j

SMILES Oc1ccccc1Cn1cncc1-c1cc2cc(Br)ccc2[nH]1

InChI Key InChIKey=OGEAFRJSWWFKAT-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50287582   

TargetIndoleamine 2,3-dioxygenase 1(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50287582(CHEMBL4174828 | US11572354, Compound 9j)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of recombinant human IDO1 assessed as reduction in kynurenine production using L-tryptophan as substrate after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50287582(CHEMBL4174828 | US11572354, Compound 9j)
Affinity DataEC50:  5.01E+3nMAssay Description:Inhibition of human IDO1 expressed in HEK293 cells assessed as reduction in kynurenine production after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50287582(CHEMBL4174828 | US11572354, Compound 9j)
Affinity DataIC50: 6.00E+3nMAssay Description:A standard reaction mixture (200uL/well) containing 50mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH), 200 ug/mL ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
Go to US Patent