BDBM50287687 CHEMBL4163281

SMILES COc1ccc(CNC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)c2cccc(NC(N)=N)c2)cc1

InChI Key InChIKey=MIFZAPHWMCAHQZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50287687   

TargetIntegrin alpha-V/beta-3(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM50287687(CHEMBL4163281)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of vitronectin binding to human alphaVbeta3 integrin after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM50287687(CHEMBL4163281)
Affinity DataIC50: 40nMAssay Description:Inhibition of fibronectin binding to soluble alpha5beta1 integrin (unknown origin) after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM50287687(CHEMBL4163281)
Affinity DataIC50: 720nMAssay Description:Displacement of p53 from MDM2 in human U87MG cells incubated for 10 mins by sandwich ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMed
TargetProtein Mdm4(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM50287687(CHEMBL4163281)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of p53 from MDM4 in human SHSY-5Y cells incubated for 10 mins by sandwich ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMed