BDBM50289326 6-(3,4-Difluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-thiazolo[3,2-b][1,2,4]triazole::CHEMBL348645

SMILES CS(=O)(=O)c1ccc(cc1)-c1sc2ncnn2c1-c1ccc(F)c(F)c1

InChI Key InChIKey=NUWWHYSJFNQYIP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50289326   

TargetProstaglandin G/H synthase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289326(6-(3,4-Difluoro-phenyl)-5-(4-methanesulfonyl-pheny...)
Affinity DataIC50: 3.00E+4nMAssay Description:Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 1 in chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProstaglandin G/H synthase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289326(6-(3,4-Difluoro-phenyl)-5-(4-methanesulfonyl-pheny...)
Affinity DataIC50: 48nMAssay Description:In vivo ability to inhibit Prostaglandin G/H synthase 2 in human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProstaglandin G/H synthase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289326(6-(3,4-Difluoro-phenyl)-5-(4-methanesulfonyl-pheny...)
Affinity DataIC50: 3.00E+4nMAssay Description:In vivo ability to inhibit Prostaglandin G/H synthase 2 in human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProstaglandin G/H synthase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289326(6-(3,4-Difluoro-phenyl)-5-(4-methanesulfonyl-pheny...)
Affinity DataIC50: 4.79E+7nMAssay Description:Inhibition of COX2 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article